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Women’s ovaries and adrenal glands do provide a modest amount of testosterone- one-tenth to one-twelfth in the blood. When the ovaries shut down during menopause, the quantity is cut in half. Women who opt for ERT usually notice a lessening of hot flashes and other symptoms. However, a small number of women do not. Researchers believe that these women may be more sensitive to the accompanying loss of testosterone. It has been noticed that many women respond positively when a dash of testosterone is added to their ERT program. Notably, libido and energy seem to be replenished.
However, more research is needed to determine if the benefits outweigh the risks. Possible side effects of TRT in women can range from masculinization, including unnatural body hair growth and deep voice to acne, oily skin, higher blood pressure, and an increased risk of heart disease.
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Uptil now, chemotherapy or surgery was by far the only way out for ovarian cancer patients but now, the researchers at the University of Edinburgh have proved that hormone therapy can also help in giving a life extension to these patients. It has been proved by them that anti-oestrogen drug can give them an added life of about three years and can also be helpful in delaying chemotherapy in some.
The study, published in Clinical Cancer Research, talks about Letrozole hormone therapy which attacks cancer by turning off its oestrogen supply. This therapy has already been used successfully in treatment of breast tumours and now the scientists believe that the same blocking technique can slow the growth and spread of ovarian cancers which are again highly sensitive to oestrogen.
The research programme led by John F. Smyth, Professor of Medical Oncology at the University of Edinburgh, and funded by Cancer Research UK involved 44 women with high oestrogen receptor (ER) levels, whose cancer had relapsed after surgery and chemotherapy.
In the study, the scientists used a blood-borne tumour marker, CA-125, to track the progress of tumours during hormone treatment. They discovered that one quarter of the women showed no tumour growth after six months of anti-oestrogen therapy, and 33 per cent of the group with the greatest ER values showed a positive response which delayed the use of chemotherapy.
Smyth quoted, “This is an important landmark in the research and treatment of ovarian cancer. Despite intense scientific research over the past 20 years, there have been few new leads in our understanding of how this disease operates. But this study suggests that the addition of hormone therapy to our treatment strategy could extend and improve the lives of women with cancer.”
Dr Simon Langdon, senior lecturer in cancer research at the University of Edinburgh and the lead scientist behind this trial, said: “Ovarian cancer can be a devastating disease, so this new discovery is particularly exciting. We still have a lot to do, but this research has furthered our understanding of the hormone control of ovarian cancer, which could provide less gruelling treatments for cancer patients. It presents new possibilities for tailor-made cancer therapy and demands further investigation.”
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Now the medicine and the HGH industry has reasons to smile because Cornell biological engineers have developed a new method which offers an efficient way to make proteins for use in medicine or HGH industry without the use of live cells.
Current methods employ vats of genetically modified bacteria or mammalian cells that churn out proteins for such pharmaceuticals as insulin or human growth hormone (hgh). But there are many proteins that bacteria or cells cannot tolerate and would kill the host if overproduced inside a cell. With this new method many such proteins can be made which cannot be produced by current biotechnology.
Researchers have tried mixing DNA that codes for the desired protein with the amino acids from which proteins are made along with ribosomes (cell structures that assemble proteins) and other helper chemicals in a test tube. Cornell’s faster, more efficient process weaves the coding DNA into an artificial gel made of synthetic DNA.
Pads of P-gel, each about 1 millimeter square, in which DNA has been embedded to code for a fluorescent compound.
Luo’s group has pioneered the use of synthetic DNA as a self-assembling construction material. Strands of DNA that are designed to be complementary over a small part of their length can join together into various shapes. In this application they form crosses, which in turn link at their ends to form a 3-D matrix. This makes a hydrogel, a spongy material that absorbs water without dissolving in the water.
To make a protein-producing gel, which Luo calls a P-gel, the synthetic DNA is also made to include sequences that join to the ends of plasmids — strands of DNA that code for the desired protein. A mix of X-shaped and plasmid DNA then assembles into a gel with genes coding for the desired protein integrated throughout. To increase the surface area for reaction, tiny drops of the P-gel are molded into pads about 1 millimeter square by 20 microns (millionths of a meter) thick. Several hundred pads are then placed in a solution of amino acids and protein-making machinery extracted from living cells.
The result, Luo reports, is to produce proteins up to 300 times more efficiently than when the same reactions are carried out with DNA floating freely in the same solution. The system has so far been tested with 16 proteins, including several that are toxic or would otherwise be impossible to make in living cells.
(Source: http://www.physorg.com/)
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There are various diets around today and one of them is the Atkins diet, which is based on the principle of much protein and low carbohydrates. It is scientifically proved that this diet improves healthy living, improves triglycerides and increases good cholesterol, lowers pressure, reduces blood glucose and improves insulin sensitivity. Also in comparison to diets based on the low-fat principle, it does not lead to extensive loss of muscle mass. It further leads to upliftment of moods and prevents depressive illnesses. The last but not the least advantage is that people do not have to do without their favorite meals. Steak and butter, cream and cake is allowed again and not forbidden in Atkins diet.
Anyone living on Atkins diet needs to find his or her personal carbohydrate level. Dr. Atkins states that people react in different ways and that everybody has its own level of carbohydrate tolerance. That is to say that some people gain weight when eating 90 grams of carbohydrate daily while others can eat 120 grams. In the phase of weight loss and in the pre-maintenance phase the personal carbohydrate count is detected. The personal level will help not to gain weight a life long.
To list the disadvantages of this diet, we begin with the fact that it is tiring and cumbersome, especially in the beginning, to have to count the carbohydrates of everything you eat. Another aspect is the Induction and many people do quit because they cannot cope with induction.
In the first week of the diet some people also experience the so called carb crash. The body reacts to the unusual food: Ketosis occurs when the organism is running in fat instead of carbs. This reaction does not last long but many people cannot face it and give up.
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In studies done by scientists, physical fitness has been determined to be a more important factor in longevity than high blood pressure, sky-high cholesterol levels, or bad habits such as smoking. In fact, researchers found that men with the lowest exercise capacity were roughly four times more likely to die during the study than the fittest participants. Altogether, physical fitness was shown to have a greater impact on the risk of death than all other well-published risk factors for heart disease.
Recent studies have shown that exercise may also fight mental aging as well as physical aging. Because exercise helps normalize brain chemistry and restore mental equilibrium, studies are pointing to regular physical activity as an effective alternative or counterpart to psychotherapy for people who suffer from mild to moderate depression. And unlike many medications, exercise delivers positive side effects. Physical activity calms the nerves of people who feel anxious and agitated, and invigorates those feel lethargic and tired. It can also improve appetite for people who don’t feel like eating and reduce food cravings in those prone to overeating.
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Our skin is at the mercy of free-radical damage. Free radicals are highly charged molecules that steal electrons from other molecules, a cycle that results in the production of reactive oxygen species, the accumulation of which in cells is associated with more than 100 human clinical conditions, including autoimmune diseases, heart disease, and cancers. While skin possesses an extremely efficient and unique anti-oxidant activity level that surpasses that of other tissues, scientists have observed that skin releases low molecular weight anti-oxidants from its surface in an age-dependent fashion. When subjected to oxidative stress and aging, LMWA release is decreases and levels of free radicals rise. An important mechanism that may contribute to free-radical damage in skin is micro inflammation which can cause inelasticity and thinning of the skin. Scientists have observed that surface peroxides form when the turnover fo macromolecules in the dermis is imbalanced, and this peroxide accumulation can be reversed by the application of topical antioxidants.
To protect and beautify your anti-aging survival suit, scientists have identified about hundreds of cutting-edge, advanced anti-aging skincare ingredients some of which include allantoin, camellia sinensis extract, ceramides, chamomile oil, glycerin, DHEA, acid and many others.
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Women may have more reason to measure their TSH levels than men. This is because nearly all women who are diagnosed with high levels of TSH have some form of hypothyroidism. In fact, hypothyroidism is much more common in women than in men. Treatment, however, has certain complications.
Studies have shown that thyroid hormone increase bone mineral re-absorption, increasing the risk of osteoporosis, especially in postmenopausal women. One study found that women being treated with enough thyroxine, prescription thyroid hormone, to suppress TSH for ten years or more had a 9 percent decrease in bone density. Patients with conditions such as goiters or thyroid cancer must receive TSH- suppressive doses of thyroxine and, therefore, are at a particularly high risk for osteoporosis.
Women who want to check the functioning of their thyroid or who are presently taking thyroid replacement hormones- especially older women- should be screened with this highly sensitive TSH assay around age forty-five, and then follow up with a screening every two years. This is to ensure that their thyroid is functioning properly and that there is no overtreatment with TH, which would increase the risk of osteoporosis.
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Rye extract is rich in vitamins, minerals, enzymes, and phytochemicals such as lignana, isoflavones, and beta 1.3 glucan.
Rye is commonly used to treat colds, flu, rashes, wounds, burns, fatigue, teethe and gums and cold sores. Coenzyme Q10 is thought to treat heart disease and lower high blood pressure and as such rye extract may be beneficial for the cardiovascular system in general. Beta 1.3 glucan, which is also found in the extract, is known to help the immune system, fight bacterial, viral, fungal, and parasitic infections by activating key immune cells known as macrophages. Studies have shown that rye extract can also improve the symptoms of benign prostatic hyperplasia.
Rye extract is available in drops, creams, gels and sprays. By far, no side effect of this product has been reported. However, those with an allergy to rye should not take rye extract.
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Although many women take estrogen supplements, many also report feeling worried, skeptical, or discouraged about the effects. Natural supplements may be the solution for these women. However, nutritional therapies are not nearly as powerful as hormone supplementation. Women may also benefit from a healthy regimen which includes not smoking, moderate alcohol intake, regular aerobic exercise (twenty to thirty minutes, three to five times a week), a low-fat, high fiber diet, and vitamin and mineral supplements. Indeed, many women have reported that their menopausal symptoms eased or disappeared as they paid more attention to diet and exercise.
Making a decision about going on HRT can be difficult- but it is a decision that virtually all women over forty have to face sooner or later. Knowing the facts can help. So, too, can coming to terms with your own responses to aging. Women approaching, entering, or living with menopause can derive huge benefits from holistic approach to easing this stage in their lives, considering hormone therapy, diet and lifestyle, and emotional support as they seek the treatment that is right for them.
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It has become a rage among the middle-aged men who are spending as much as $15,000 an year on human growth hormone in an attempt to arrest their youth. Although. The FDA has strict rules that only children with growth disorders and adults with severe hormone deficiencies can be precribed with HGH, a Sunday Age investigation has found many anti-ageing clinics in Melbourne’s wealthier suburbs are flouting regulations by prescribing to people as young as 35 who want to look good, stay fit and boost their sex lives.
Because possession of HGH without a prescription is illegal and its import is prohibited, black-market sales are booming, so much so that a former dealer claims that $5000 worth of the drug can fetch up to $50,000 on the street.
Australian Customs has reported a four-fold increase in HGH seizures in the last year. Imports from China have risen steeply but the United States remains the main source of supply. Gabrielle Caswell, from the Cosmetic Physicians Society of Australia, said demand for HGH soared in 2007 after Hollywood star Sylvester Stallone was caught at Sydney Airport trying to bring 48 vials of the drug into Australia.
John Levin, a 77-year-old Prahran doctor, has been injecting the drug for 15 years and prescribes it to 100 patients who want to delay old age. He says 70 per cent are men and insists there are no health risks at low doses, typically less than 0.33 milligrams a day.
“I feel great, I feel like I’m 50 — and I’m going to be 80 in two years,” Dr Levin said. “I don’t give it to my patients for aesthetic reasons. I give it purely to get a better quality of life.”
Ken Ho, chair of endocrinology at St Vincent’s Hospital in Sydney, said misuse could increase the risk of cancer and elongate the jaw. Professor Ho said the medical properties of HGH were being exploited by anti-ageing clinics.
“They are trying to sell an expectation that if you’re 55 and you no longer have the body of a 21-year-old, then you can reclaim former glories by taking these drugs. There are claims about improved sex life, which are completely unfounded … They are trying to tell you that ageing is an insidious disease, but there is no hormone that can stop ageing.”
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