Do Human Growth Hormones increase the risk of Cancer?
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One of the important functions of Human Growth Hormones is growth. That is the main reason why HGH is highest at the growing age and diminishes once a being reaches maturity. HGH therapy works with supplementation and stimulation of Growth Hormones which in turn leads to cell growth and multiplication. But, is increase in the number of cells always beneficial? No, and possibly this is the reason why Human Growth Hormones are said to increase the risk of cancer.
Now, what is cancer? According to the American Cancer Society (ACS), cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. In cancer, the increased cells don’t do the work which original cells do. So, it is said that if the dose of HGH is not properly administered it may lead to malfunctioned and uncontrolled cell growth leading to cancer. Several studies have been conducted to find out the relation between human growth hormone use and cancer.
Human Growth Hormones stimulate the liver to increase production of the natural Insulin-like Growth Factor-1 (IGF-1). However, there are scientific journals showing that elevated IGF-1 levels are strongly associated with major excess risks of colon, prostate, and breast cancers. IGF-1 is suspected to be the major culprit behind growth of cancer cells and it is said that even minor elevations are associated with up to 7-fold increased risks of breast cancer, risks almost as high as those in women carrying genes (BRCA1 and BRCA2) with the strongest hereditary predisposition. In addition to this, IGF-1 also obstructs and inhibits the programmed self-destruction (apoptosis) of cancer cells, thus stimulating the growth and invasiveness of small, undiagnosed cancers, besides increasing the resistance of cancers to chemotherapy. Also medical science has shown the likeliness of IGF-1 promoting transformation of normal breast cells to breast cancers. In addition, IGF-1 maintains the malignancy of human breast cancer cells, including their invasiveness and ability to spread to distant organs. The side-effect is more so in the prenatal and infant breasts.
However, the conclusive relation between HGH supplementation and cancer is yet to be established. Studies have shown conflicting results about HGH’s role in causing cancer and its effect on the cardiovascular system. But because of its yet to be verified side-effects, Human Growth Hormones are still a controlled substance in many nations. In 1985, it has been recommended by FDA that human growth hormone medication should be prescribed only by the qualified endocrinologists for highly restricted medical disorders, such as dwarfism due to pituitary gland deficiency.
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