HGH deficiency brings decreased well-being and shortens life span
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People who produce little or no HGH as a result of pituitary tumors, disease, or removal of the pituitary gland often seem like old doddering people. In studies, such patients show a consistent pattern of mental and physical characteristics associated with aging. The psychological and emotional symptoms include a reduced sense of well-being, low energy, vitality, and capacity for work, and emotional liability, including mood swings, anxiety, depression, and increased social isolation. Important physical signs are increased body fat, especially around the waist, decreased muscle mass, and thin, wrinkled, or prematurely aged skin.
Bengt-Ake Bengtsson, M>D>, and his colleagues at Salgrenska Hospital in Goteburg, Sweden, studied 333 patients who had been diagnosed with pituitary insufficiency in a thirty-year period between 1956 and 1987. All these patients had been treated with pituitary hormone replacement, including cortisone, thyroid hormones and sex hormones. The one hormone that was not replaced was HGH. The HGH-deficient patients died at twice the expected rate- 107 deaths compared with 57 in the overall population matched for age and sex. The primary cause of death was cardiovascular disease, which showed an almost twofold increase with 60 deaths versus 31 in the general population.
Thus growth hormone deficiency is now formally recognized as a specific clinical syndrome, typified by decreases muscle mass, increases body fat, decreased exercise capacity, abnormal lipid profiles, diminished sense of well-being and other signs common in an aging patient population.
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