Role of HGH in glucose metabolism
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Growth hormone enhances the movement of amino acids through the cellular membrane into the cell. It causes the fatty tissue to release stored fatty acids, which are then preferentially metabolized or burned for energy.
Growth hormone has a number of effects on the cellular metabolism of glucose, the primary carbohydrate in the body that is used as a fuel. Growth hormone decreases the utilization of glucose for energy in the cell and increases the formation and deposition of a substance called glycogen in the cell. Glycogen is the storage form of glucose that is stored within the cell, especially the cells of muscle and the liver, and can be mobilized for quick energy. This may be due in part to the increased use of fatty acids for energy, which may cause the cell to shut down the process in which glucose is converted into energy. Growth hormone also has the ability to increase the secretion of insulin from the pancreas and causes a mild insulin resistance, which decreases the uptake of glucose by the cell. The mild insulin resistance is temporary and allows growth hormone to limit the muscle’s use of glucose as a fuel and increase the use of fatty acids for fuel.
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