The pros and cons of Progestin - The synthetic progesterone
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Progesterone is the gestational hormone that prepares the lining of the uterus for the fertilized ovum and maintains pregnancy. It is derived primarily from the corpus luteum that is formed in the ovary from the ruptured follicle. it is also produced in the placenta during pregnancy and in small amounts by the adrenal cortex. Progesterone is a ‘precursor’ hormone. This means that it can be converted by the body into other steroid hormones.
When ERT was first put into practice, estrogen was generally prescribed alone. Doctors later discovered that it was more effective and often safer in combination with progesterone.
Artificially produced progesterone are synthetic hormones that closely resemble the body’s own production of progesterone, but different in important ways. Both natural and synthetic hormones share the ability to sustain the lining of the vagina and uterus but progestins do not have the full range of biological activity of natural progesterone. Progestin has actually been shown to inhibit biosynthesis of progesterone.
However, the benefits of progestin are not without side effects. Women, who are engaged in HRT, filling their prescriptions with synthetic progesterone, are exposing themselves to unnecessary risks like abnormal menstrual flow or cessation, fluid retention, nausea, insomnia, jaundice, depression, fever, weight fluctuations, allergic reactions, and the development of male characteristics.
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