Tribulus terrestris has been used in centuries for traditional Ayurvedic medicine. The active ingredients are extracted from the fruits, which contain alkaloids, resins, tannins, saponins, sugars, sterols, essential oil, peroxidase, diastase, and glucoside.

Tribulus terristris is a proven herbal remedy for depression, as harmine, the main active ingredient of the plant, is a very effective monoamine oxidase inhibiter. Many antidepressants used in conventional medicine are MAOIs, which work by gradually increasing levels of the neurotransmitter dopamine.

High dopamine levels in men are known to stimulate the pituitary gland to release lutenizing hormones, which leads to an increase testosterone levels. As recent studies have suggested that older may benefit from hormone replacement therapy, the herb may be of benefit in this area. High dopamine levels also lead to an increased production of growth hormone, in both men and women.

The sapomine of tribulus terrestris dilates coronary artery and improves coronary circulation, and thus improves EGC related to myocardial ischemia. Furthermore, chronic administration had no adverse reaction on blood system and hepatic and renal functions.

The vasodilatory properties of the herb may take it useful for patients with heart disease, high blood pressure, and atherosclerosis.

Tribulus terrestris should not be taken by pregnant women or children or by anyone with psychosis, schizophrenia, or phaeochromocytoma. In addition, it should not be taken in combination with psychoactive medicines, such as tranquillizers, sedatives, stimulants and antidepressants.