Weight increase and HGH decrease is a vicious cycle
Anti aging, Guide, HGH: Human Growth Hormone, HgH, Hgh Effects, News, Review, Weight loss
It is said that fat cells increase with decrease of human growth hormones secretion in the body, but it is true at the same time that as weight increases, HGH secretion decreases. In addition, increasing body fat decreases the effectiveness of HGH. Again, this decline in HGH is mainly related to abdominal visceral fat (mid to lower abdomen, including mesenteric fat surrounding the intestines).
In a study of factors affecting 24-hour HGH release by the pituitary gland, the strongest factor to affect HGH secretion was the amount of abdominal visceral fat, independent of age. Again, next factor was that HGH decreases inversely with higher fasting serum insulin levels (i.e., loss of tissue sensitivity to insulin with increasing blood insulin levels and carbohydrate intolerance decreases HGH release by the pituitary).
Medical science has postulated the fact that abdominal visceral fat leads to more insulin resistance, elevated blood insulin levels, which in turn act to inhibit the hypothalamus in the base of the brain, uncoupling HGH release.
Insulin and IGF-1 have similarities. Insulin probably acts to block or otherwise affect IGF-1 receptors or perhaps insulin acts to displace IGF-1 from its binding protein, allowing more free IGF-1 to feed back negatively on the hypothalamus.
Both HGH and IGF-1 decline with age. So, with age there is an increase in abdominal visceral fat, which again results in more production of insulin. Increased insulin production leads to declining HGH, thus creating a cycle that reinforces itself, a so-called vicious cycle.
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